Job Description

Ihre Aufgaben



Background and Project Description

Synapses are essential cellular structures where tightly regulated local protein synthesis and turnover underpin neuronal communication and plasticity. The spatial and temporal control of mRNAs and their binding proteins at synapses is critical for maintaining synaptic vesicle cluster stability and neuronal function. Despite advances in understanding synapse structure, the molecular mechanisms governing synaptic protein turnover and RNA localization during activity remain largely unknown.

This PhD project aims to unravel how mRNA-binding proteins orchestrate synaptic protein turnover, RNA localization, and synaptic vesicle cluster stability at the cellular and molecular level. You will apply cutting-edge molecular neuroscience techniques, including spatial transcriptomics, proteomics, and advanced imaging, to generate comprehensive datasets of synaptic compartments.

Integrating these datasets, you will develop and apply quantitative computational models and network analysis to identify regulatory pathways controlling synaptic function. Your computational predictions will guide targeted functional experiments providing mechanistic insights into the molecular regulation of synaptic stability.



Ihre Qualifikationen



Requirements



Master’s degree (or equivalent) in Life Sciences with a strong academic record Strong interest in cellular and molecular neuroscience Data analysis and programming skills are required and will be actively used and developed in this project Basic experience in wet lab work is necessary High level of motivation, initiative, and a strong research orientation Excellent communication and teamwork skills Fluent written and spoken English

Application documents



Curriculum Vitae (CV) Motivation letter explaining your interest and suitability for the project University transcripts

Wir bieten



We offer



A 65% PhD position with payment and benefits according to the German Public Service Payscale (TV-L) Structured doctoral training through the Göttingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences (GAUSS / GGNB) Work in a highly international and interdisciplinary team Access to a well-equipped laboratory, including a state-of-the-art imaging facility Opportunities for national and international collaborations Organized networking events and personalized supervision

Einleitungstext

PhD Position (65%/ TVL):

Molecular/Computational Mechanisms of Synaptic Regulation

The Institute for Neuro and Sensory Physiology, University Medical Center Göttingen (UMG), Göttingen, Germany offers a position as PhD Student (m/f/d).

The successful candidate will join the lab of Dr. Eugenio F. Fornasiero working on the molecular mechanisms regulating the stability of synaptic components.