Job Description

The University Medical Center Göttingen (UMG) unites the Medical Faculty of the Georg-August University and the University Hospital in an integration model. With around 9,700 employees, the UMG and its subsidiaries are one of the largest employers in the region. Our clinics and institutes stand for high-quality patient care, excellent research, modern teaching and transfer of innovative technology.




Göttingen as a city of science is located in the center of Germany and the University Medical Center Göttingen is integrated into an attractive network of university and non-university scientific institutions.


The Klinik für Neurologie of the University Medical Center Göttingen is looking for a new position for the earliest start date

Postdoc (f/m/d)

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full time , 2 Jahre


The research group ‘Cell Biology of Neurodegeneration’ headed by Dr. C. A. Boecker (m) is offering a position for a Postdoc (f/m/d).




We are looking for a Postdoc to join our team and contribute to a fully funded research pproject investigating the role of LRRK2 in the pathogenesis of Parkinson´s disease. The postition is funded by theMichael J. Fox Foundation and scheduled to start on October 1st, 2025.




In collaboration with the groups of Sabine Hilfiker (Rutgers University, USA) and Luis Bonet-Ponce (The Ohio State University, USA), we will decipher how hyperactive LRRK2 kinase activity disrupts the intracellular pathways of axonal autophagosome transport, ciliogenesis/centriole cohesion and lysosomal membrane dynamics.




LRRK2 mutations are the most common genetic cause of Parkinson´s disease an lead to pathogenitc hyperactivation of LRRK2 kinase. The results in hyperphosphorylation of RAB proteins and interferes with the above processes. Although these cellular deficits are all mediated by similar phospho-RAB effector protein interactions, it remains unclear whether they share a common core mechanism. I this collaborative project we will determine whether the effects of LRRK2 are cell type-specific, address the interdependence of autophagosome, ciliogenesis/centriole cohesion and lysosomal dynamics alterations, and determine common versus pathway-specific molecular mechanisms downstream ofphospho-RAB effector recruitment.